Malotilate
CAS No. : 59937-28-9
(Synonyms: NKK 105)
| Size | Price | Stock |
|---|---|---|
| 5mg | $30 | In-stock |
| 10mg | $40 | In-stock |
| 25mg | $60 | In-stock |
| 50mg | $85 | In-stock |
| 100mg | $120 | In-stock |
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| Cat. No. : | HY-A0060 |
| M.Wt: | 288.38 |
| Formula: | C12H16O4S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes[1][2].
In Vitro: Malotilate reduces collagen synthesis and cell migration activity of fibroblasts in vitro[3].
Malotilate, an anti-fibrotic substance, selectively inhibited the 5-lipoxygenase, whereas both the 12- and the 15-lipoxygenase pathways are stimulated. Malotilate has been shown to prevent acute experimental liver injury induced by several hepatotoxic compounds, including Ahyl alcohot, Bromobenzene, Carbon tetrachloride, ChIoroform, Dimethylnitrosamine and Thioacetamide[4].
In Vivo: Malotilate (100 mg/kg; p.o.; daily for 3 days) treatment in rats with hypocholesterolemia results in a rapid normalization of lowered serum cholesterol[5].
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