Hh Pathway-IN-1
CAS No. : 599150-20-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $50 | In-stock |
| 5mg | $115 | In-stock |
| 10mg | $174 | In-stock |
| 25mg | $298 | In-stock |
| 50mg | $442 | In-stock |
| 100mg | $617 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-107551 |
| M.Wt: | 463.53 |
| Formula: | C27H29NO6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Hh Pathway-IN-1, a Hedgehog (Hh) pathway inhibitor, is a potent Gli antagonist. Hh Pathway-IN-1 inhibits Hh pathway functional with an IC50 value of 1.1 µM in C3H10T1/2 cells. Hh Pathway-IN-1 does not inhibit Wnt signaling. Hh Pathway-IN-1 shows anti-proliferative activity. Hh Pathway-IN-1 decreases the GLI1 mRNA expression. Hh Pathway-IN-1 inhibits colony formation in a dose-dependent manner[1][2].
IC50 & Target:IC50: 1.1 µM (GLI)[1]
In Vitro:Hh Pathway-IN-1 (compound HPI-1) (0-25 μM; 72 h) shows anti-proliferative activity with IC50 values of 29, >25, 20.5 μM for SUM149, MDA-MB-231, SUM159 cells, respectively[1].
Hh Pathway-IN-1 (10 μM; 72 h) decreases the GLI1 mRNA expression in SUM149 cells[1].
Hh Pathway-IN-1 (5, 10, 20 μM) inhibits colony formation in a dose-dependent manner in SUM149 and MDA-MB-231 cells[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- Hh Pathway-IN-1
- Cat. No.:
- HY-107551
- Quantity:
Your information is safe with us.