Glabridin
CAS No. : 59870-68-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $25 | In-stock |
| 10mg | $40 | In-stock |
| 50mg | $100 | In-stock |
| 100mg | $160 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N0393 |
| M.Wt: | 324.37 |
| Formula: | C20H20O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Glabridin is a natural isoflavan from Glycyrrhiza glabra L., binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities[1][2].
In Vitro:Glabridin binds to and activates PPARγ, with an EC50 of 6115 nM[1].
Glabridin (40, 80 μM) inhibits the proliferation of SCC-9 and SAS cell lines in a dose- and time-dependent manner after treatment for 24 and 48 h[2].
Glabridin (0-80 μM) also induces apoptosis, causes Sub-G1 cell cycle arrest in SCC-9 and SAS cell lines[2].
Glabridin (0, 20, 40, and 80 μM) dose-dependently activates caspase-3, 8, and 9 and increases PARP cleavage, significantly phosphorylates ERK1/2, JNK1/2, and p-38 MAPK in SCC-9 cells[2].
In Vivo:Glabridin (50 mg/kg, p.o. once daily) shows potent anti-inflammatory activity, ameliorates the inflammatory alterations induced by Dextran sodium sulphate (DSS) in rats[3].
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