Multi-kinase-IN-12
CAS No. : 597544-21-3
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| Cat. No. : | HY-18692 |
| M.Wt: | 401.47 |
| Formula: | C23H23N5O2 |
| Purity: | >98 % |
| Solubility: |
Multi-kinase-IN-12 is a non-selective multi-target inhibitor, with IC50 values against human targets as follows: Flt3 < 0.001 μM, c-Src 0.002 μM, KDR 0.004 μM, Eph-A2, MNK-1 and Flt1 0.011 μM, Lck 0.016 μM, Rsk1 0.21 μM, and α2 subunit of AMPK 0.041 μM. Multi-kinase-IN-12 can be used in research related to solid tumors[1].
In Vitro:Multi-kinase-IN-12 potently inhibits the recombinant human AMPK α2/β1/γ1 heterotrimer with an IC50 of 0.04 μM[1].
Multi-kinase-IN-12 (1-10 μM; 6 h) inhibits cellular AMPK activity in MEF cells (detected via the phosphorylation level of ACC), with significant inhibition observed following treatment with 10 μM for 6 hours[1].
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