Fexinidazole
CAS No. : 59729-37-2
(Synonyms: HOE 239)
| Size | Price | Stock |
|---|---|---|
| 5mg | $85 | In-stock |
| 10mg | $135 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $400 | In-stock |
| 100mg | $600 | In-stock |
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| Cat. No. : | HY-13801 |
| M.Wt: | 279.31 |
| Formula: | C12H13N3O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : < 0.1 mg/mL |
Fexinidazole (HOE 239) is an orally active, potent nitroimidazole antitrypanosomal drug. Fexinidazole shows trypanocidal activity against T. brucei subspecies and strains with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml). Fexinidazol has the potential for human sleeping sickness (HAT) caused by infection with T. brucei[1].
In Vitro: Fexinidazole (HOE 239) has two principal metabolites, sulfoxide and sulfone. They have shown trypanocidal activity in vitro with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml) range against all parasite strains tested[1].
In Vivo: Fexinidazole (HOE 239; 20-50 mg/kg/day of IP or 25-100 mg/kg/day of PO; four consecutive days) has antitrypanosomal activities[1].
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