Citalopram (hydrobromide)
CAS No. : 59729-32-7
(Synonyms: (±)-Citalopram (hydrobromide); Lu 10-171)
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|---|---|---|
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| 10mg | $50 | In-stock |
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| Cat. No. : | HY-B1287 |
| M.Wt: | 405.30 |
| Formula: | C20H22BrFN2O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 38 mg/mL;H2O : 10 mg/mL (ultrasonic) |
Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI), with blood-brain barrier permeability. Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant effect[1][2][3]. In Vitro: Citalopram（25-150 μM) shows a concentration-dependent cytotoxicity on the viability of rat B104, human SH-SY5Y, IMR32 and Kelly neuroblastoma cell lines and human primary Schwann cells (HSC)[2]. In Vivo: Acute administration of Citalopram (1-10 mg/kg, i.p. 1 h before an elevated plus-maze test) to Spontaneously Hypertensive rats (SHRs), Lewis (LEW) rats, and Wistar-Kyoto (WKY) rats, i.e., rat strains differing for their emotionality, promotes anxiety, and/or hypoactivity, except in WKY rats. In the three strains, such a pretreatment increased central 5-HT levels and/or decreased 5-hydroxyindoleacetic acid levels[3].
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