Piperacillin (sodium)
CAS No. : 59703-84-3
(Synonyms: Sodium piperacillin)
| Size | Price | Stock |
|---|---|---|
| 25mg | $30 | In-stock |
| 50mg | $50 | In-stock |
| 100mg | $72 | In-stock |
| 200mg | $110 | In-stock |
| 1g | $275 | In-stock |
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| 10 g | Get quote | |
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| Cat. No. : | HY-B1286 |
| M.Wt: | 539.54 |
| Formula: | C23H26N5NaO7S |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 100 mg/mL;DMSO : 100 mg/mL (ultrasonic) |
Piperacillin sodium is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin is most commonly used in combination with the β-lactamase inhibitor Tazobactam[1][2][3].
IC50 & Target:penicillin-binding proteins
In Vitro:Piperacillin (12.5 μg/mL, 24h) inhibits 92% of isolates of Pseudomonas aeruginosa, 82% of Serratia marcescens, 73% of Escherichia coli, 61% of Klebsiella spp, and 42% of Enterobacter spp, most Proteus spp. were extremely susceptible. Piperacillin fails to inhibit the growth of gram-negative bacilli when large inocula were used (minimum inhibitory concentration > 25 μg/ml) [2].
In Vivo:Piperacillin (100 mg/kg, i.v., 4 times a day, 5 d) in combination with Tazobactam (HY-B1418)(12.5 mg/kg, i.v., 4 times a day, 5 d) prolongs survival in mice with low inoculum of K. pneumoniae[3].
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