1'-Hydroxymidazolam
CAS No. : 59468-90-5
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| Cat. No. : | HY-118645 |
| M.Wt: | 341.77 |
| Formula: | C18H13ClFN3O |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (ultrasonic;warming);DMF : 2 mg/mL (ultrasonic;warming) |
1'-Hydroxymidazolam is a primary active metabolite of Midazolam, and it is a neuronal depressant agent. 1'-Hydroxymidazolam could inhibit neuronal activity add to the effects of Midazolam[1][2]. In Vitro: 1'-Hydroxymidazolam (5?nM-1?μM) induces a significant inhibition of the action potential firing rate at concentrations of 100?nM or higher and causes a steady increase in the depression of network activity with increasing concentrations of up to 1?μM in neocortical slice cultures from wild-type mice[2].
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