Nikkomycin Z
CAS No. : 59456-70-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $465 | In-stock |
| 5mg | $1400 | In-stock |
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| Cat. No. : | HY-19593 |
| M.Wt: | 495.44 |
| Formula: | C20H25N5O10 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 31.25 mg/mL |
Nikkomycin Z is a nucleoside peptide and an orally active antifungal agent. Nikkomycin Z inhibits chitin synthesis by acting as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine. Nikkomycin Z has antifungal activity[1][2][3]. In Vitro:Nikkomycin Z (0.03-32 mg/L; 24 h) inhibits the growth and biofilm formation of Candida albicans and Candida parapsilosis, and shows better efficacy when used in combination with echinocandins, such as Caspofungin (HY-17006A) and Micafungin (HY-17579)[1]. In Vivo:Nikkomycin Z (Oral gavage; 20-100 mg/kg; twice a day; 10 days) reduces the fungal burden and prolongs the survival period of mice in a murine model of Histoplasma capsulatum infection[2].
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