TNKS-IN-1
CAS No. : 59455-93-5
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| Cat. No. : | HY-114943 |
| M.Wt: | 278.36 |
| Formula: | C18H18N2O |
| Purity: | >98 % |
| Solubility: |
TNKS-IN-1 is a selective and potent tankyrase (TNKS1/TNKS2) inhibitor with IC50 values of 7.9 nM and 8.7 nM. TNKS-IN-1 induces axin2 accumulation with an EC50 of 1500 nM. TNKS-IN-1 can antagonize the Wnt signal transduction pathway by stabilizing axin proteins and promoting β-catenin degradation. TNKS-IN-1 can be used for the research of colorectal cancer[1].
In Vitro:TNKS-IN-1 (Compound 3a) (1 h) potently inhibits purified human TNKS1 and TNKS2 with IC50 values of 7.9 nM and 8.7 nM, respectively, and exhibits >10000 nM for PARP1[1].
TNKS-IN-1 (24 h) induces axin2 accumulation in DLD1 cells with an EC50 of 1500 nM, confirming cellular tankyrase inhibition activity[1].
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