Nimbin
CAS No. : 5945-86-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $400 | In-stock |
| 5mg | $1000 | In-stock |
| 10mg | $1500 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-N3187 |
| M.Wt: | 540.60 |
| Formula: | C30H36O9 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Nimbin is an orally active intermediate limonoid found in Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin is promising for research of neurodegenerative diseases and viral infections[1][2][3][4].
In Vitro:Nimbin (400 μM; 0-120 h) inhibits β-sheet formation and reduces hydrophobicity in hTau40wt protein in heparin-induced tau aggregation assay[1].
Nimbin (50 nM-50 μM; 24 h) shows no cytotoxicity and rescues tau aggregate-induced cell death in HEK293T cells[1].
In Vivo:Nimbin reduces brain tau aggregation and improves cognitive behavior in transgenic tauopathy mouse models[1].
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