L-Histidine (hydrochloride hydrate)
CAS No. : 5934-29-2
(Synonyms: H-His-OH.HCl.H2O)
| Size | Price | Stock |
|---|---|---|
| 25g | $14 | In-stock |
| 500g | $69 | In-stock |
| 1000g | $115 | In-stock |
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| Cat. No. : | HY-W014423 |
| M.Wt: | 209.63 |
| Formula: | C6H12ClN3O3 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic);DMSO : 1 mg/mL (ultrasonic;warming;heat to 60°C) |
L-Histidine hydrochloride hydrate is an endogenous metabolite. L-Histidine hydrochloride hydrate scavenges hydroxyl radicals and singlet oxygen, regulate the absorption of zinc, copper and iron, exhibits anti-inflammatory and antioxidant activities. L-Histidine hydrochloride hydrate is blood brain barrier penetrable[1][2][3].
In Vitro:L-Histidine hydrochloride hydrate (1 mM, 20 h) enhances the cytotoxicity of H2O2, induces apoptosis by inducing DNA double-strand breaks[1].
L-Histidine hydrochloride hydrate (0.2-10 mM, 20 h) reduces zinc-induced GT1-7 cell death (ED50=0.2 mM), downregulates the expression of zinc-induced ER stress-related genes (such as GADD45, GADD34 and p8) and calcium homeostasis-related genes (such as Arc)[2].
In Vivo:L-Histidine hydrochloride hydrate (250 mg/kg, intra-rectal, 3 times a day for 5 days) exhibits anti-inflammatory efficacy in Acetic acid (HY-Y0319)-induced rats ulcerative colitis models[3].
L-Histidine hydrochloride hydrate (250 mg/kg, ip, single dose) exhibits neuroprotective efficacy in rat ischemia-reperfusion injury model[3].
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