Methoxyamine (hydrochloride)
CAS No. : 593-56-6
(Synonyms: O-Methylhydroxylamine (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 25g | $5 | In-stock |
| 100g | $17 | In-stock |
| 500g | $56 | In-stock |
| 1000g | $111 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-Y0958 |
| M.Wt: | 83.52 |
| Formula: | CH6ClNO |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents[1][2].
In Vitro:Methoxyamine (O-Methylhydroxylamine; 1 mM; 1-7 days) hydrochloride sensitizes pediatric (SJG2) GBM cells in vitro to Temozolomide (HY-17364; 100 μM) and induces apoptosis[1].
In Vivo:Compared with vehicle and Methoxyamine alone, only the mice (NOD-SCID mice injecting SJG2 cells) receiving dual treatment (65 mg/kg Temozolomide + 100 mg/kg Methoxyamine; oral gavage; daily for 2 weeks, weekends off) has a significant increase in survival[1].
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