11R-VIVIT
CAS No. : 592517-80-1
(Synonyms: Cell permeable NFAT inhibitor)
| Size | Price | Stock |
|---|---|---|
| 1mg | $290 | In-stock |
| 5mg | $725 | In-stock |
| 10mg | $1050 | In-stock |
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| Cat. No. : | HY-P1430 |
| M.Wt: | 3573.15 |
| Formula: | C147H259N67O36S |
| Purity: | >98 % |
| Solubility: |
11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT can be used for the research of podocyte and diabetic nephropathy[1]. IC50 & Target:NFAT[1] In Vitro:11R-VIVIT (100 nM) shows a significant reduction of NFAT2 expression in high glucose treated podocytes compared to podocytes treated with normal glucose. 11R-VIVIT attenuates high glucose induced filtration barrier dysfunction of podocytes[1]. In Vivo:11R-VIVIT significantly abrogates the increased urinary albumin excretion rates, attenuates glomerular basement membrane (GBM) thickening and podocyte foot process effacement, partially restores podocyte number, inhibits NFAT2 activation and uPAR expression in glomerular podocytes[1].
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