PSB-10 (hydrochloride)
CAS No. : 591771-91-4
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| Cat. No. : | HY-103177 |
| M.Wt: | 435.14 |
| Formula: | C16H15Cl4N5O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A3AR), with a Ki of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA3 over rA1, rA2A, hA1, hA2A and hA2B receptors (Ki=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice[1][2]. IC50 & Target: Ki: 0.44 nM (hA3AR)[2] In Vitro: PSB-10 hydrochloride exhibits a subnanomolar Ki value (Ki=0.43 nM versus [3H]NECA) for A3AR. In addition, R-8 is highly selective (>800-fold) versus the other AR subtypes[1]. In Vivo: PSB-10 hydrochloride (50-100 mg/kg; i.p.) dose-dependently decreases hot-plate response latencies in mice[2].
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