ZINC05007751
CAS No. : 591239-68-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $450 | In-stock |
| 50mg | $720 | In-stock |
| 100mg | $1150 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-122639 |
| M.Wt: | 304.30 |
| Formula: | C18H12N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 8.33 mg/mL (ultrasonic;warming;heat to 60°C) |
ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9[1].
In Vitro: ZINC05007751 (6 μM-190 μM; 24 hours) inhibits the growth of MDA-MB-231, PEO1, NCI-H1299 and HCT-15 with IC50 below 100?μM[1].
ZINC05007751 induces perturbation of PEO1 cell cycle[1].
ZINC05007751 (ovarian cancer cells PEO1) shows synergism with Cisplatin, resulting in a significant reduction of Cisplatin IC50 from 7.9 to 0.1??μM, with combination ZINC05007751 (44?μM)?+?Cisplatin (10?μM) exhibiting the greatest synergistic effect[1].
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