α-Angelica lactone
CAS No. : 591-12-8
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|---|---|---|
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| 25g | $50 | In-stock |
| 100g | $155 | In-stock |
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| Cat. No. : | HY-N0548 |
| M.Wt: | 98.10 |
| Formula: | C5H6O2 |
| Purity: | >98 % |
| Solubility: |
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes[1][2][3][4].
IC50 & Target:Glutathione-S-thansferase (GST) detoxification enzyme[1][2]
UDP-glucononosyltransferase (UGT) detoxification enzyme[2]
In Vitro:α-Angelica lactone (Compound 2a) (1 mmol) produces γ,γ-disubstituted butenolide in 71% yield with 94% ee under the optimal reaction conditions[3].
In Vivo:α-Angelica lactone (0.5%, incorporate in diet, daily) significantly increases the GST activity in oesophagus and stomach by 155% and 230% of Wistar rats, respectively[1].
α-Angelica lactone (0.5% w/w, incorporate in diet, daily) enhances the 4-NP UGT enzyme activity in small intestine, latge intestine, and liver of male Wistar rats[2].
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