Atropine (sulfate monohydrate)
CAS No. : 5908-99-6
(Synonyms: Tropine tropate (sulfate monohydrate); DL-Hyoscyamine (sulfate monohydrate))
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| Cat. No. : | HY-B0394 |
| M.Wt: | 347.43 |
| Formula: | C17H23NO3.1/2H2O4S.1/2H2O |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : 33.33 mg/mL (ultrasonic) |
Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia[1][2][3][4]. IC50 & Target:IC50: 0.39 nM (Human mAChR M4) and 0.71 nM (Chicken mAChR M4)[3] In Vitro:Atropine (Tropine tropate; 1 μM; pulmonary veins and arteries) sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins[4]. In Vivo:Atropine (Tropine tropate; 10 mg/kg; i.p.; once, for 40 minutes; Peromyscus sp.) sulfate monohydrate inhibits the cardiac arrhythmia which normally occurs throughout torpor[2].
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