Metamizole (sodium hydrate)
CAS No. : 5907-38-0
(Synonyms: Dipyrone (hydrate); Methamizole (sodium hydrate))
| Size | Price | Stock |
|---|---|---|
| 500mg | $25 | In-stock |
| 1g | $40 | In-stock |
| 5g | $100 | In-stock |
| 10g | $150 | In-stock |
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| Cat. No. : | HY-B1279 |
| M.Wt: | 351.35 |
| Formula: | C13H18N3NaO5S |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 100 mg/mL;DMSO : 100 mg/mL (ultrasonic) |
Metamizole sodium hydrate (Dipyrone) is an orally active cyclooxygenase (COX) inhibitor.. Metamizole sodium hydrate can inhibit cell proliferation and promote cell apoptosis. Metamizole sodium hydrate has anti-inflammatory and antioxidant activities. Metamizole sodium hydrate is an antipyretic, analgesic and spasmolytic agent. Metamizole sodium hydrate can be used in research to relieve a variety of pain[1][2][3][4][5].
IC50 & Target:COX[1]
In Vitro: Metamizole sodium hydrate (1 and 10 μM, 24 h) can inhibit osteoblast differentiation and thus reduce its ability to generate new bone mineralized extracellular matrix[2].
Metamizole sodium hydrate (1-500 μM, 48 h) can inhibit cell proliferation and promote apoptosis in pancreatic cancer cell lines PaTu 8988 t and Panc-1[3].
In Vivo: Metamizole sodium hydrate (500 mg/kg, intraperitoneal injection twice a day for 7 days) can reduce the development of neuropathic pain symptoms in rats[4].
Metamizole sodium hydrate (250 or 500 mg/kg, orally) can effectively relieve pain and oxidative stress induced by scalpel incision and carrageenan in rats[5].
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