Have any questions? [email protected] +86-21-58998590
Structure search

Nitrofurazone


CAS No. : 59-87-0

(Synonyms: Nitrofural)

59-87-0
Price and Availability of CAS No. : 59-87-0
Size Price Stock
500mg $30 In-stock
1g $40 In-stock
5g $100 In-stock
10 g Get quote
50 g Get quote
We match the lowest price on market.

We offer a substantial discount on larger orders, please inquire via [email protected]

or Fax: (86)21-58955996

Inquiry for price and availability only. Please place your order via our email or fax.

Cat. No. : HY-B0226
M.Wt: 198.14
Formula: C6H6N4O4
Purity: >98 %
Solubility: DMSO : ≥ 155 mg/mL
Introduction of 59-87-0 :

Nitrofurazone (Nitrofural) is a broad spectrum antibiotic that has oral activity. Nitrofurazone is a nitro-aromatic drug. Nitrofurazone is active against both Gram-positive and Gram-negative bacteria[1][2][3][4][5]. In Vitro:Nitrofurazone (10-20 μg/mL) can make E. coli strain B/r triple resistant mutants, increasing drug resistance by 6 to 7 times[2].
Nitrofurazone (50 μg/mL, 30 min) inhibits the synthesis of all color RNA and ribosomal subunits and the formation of polysomes in E. coli strain B/r[3].
In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Nitrofurazone can be used to create breast tumor models. The pharmacokinetic characteristics of Nitrofurazone in male white rabbits show a high clearance constant (0.04) and a short elimination half-life (17.32 minutes) with an AUC0-∞ of 844.79 when administered intravenously. When given orally, Nitrofurazone exhibits a lower clearance constant (0.002), a longer elimination half-life (276.09 minutes), and an AUC0-∞ of 566.44. After oral administration, the mean residence time of Nitrofurazone is 956.1 minutes, significantly longer than the 496.3 minutes observed after intravenous administration[4][5][6][7].

Induction of breast tumor[5]
Background
Nitrofurazone, with the involvement of cytochrome P450 reductase, generates metabolites that cause oxidative damage to the DNA of MCF-7 cells (human breast cancer-derived cells). At the same time, Amiodarone itself promotes cell proliferation and increases serum prolactin and progesterone levels in rats, thereby inducing breast cancer[4][5][6].
Specific Modeling Methods
Rat: Wistar • female • 4-week-old
Administration: diets containing 1000 ppm of Nitrofurazone • po • once daily, between 8 and 27 weeks of age
Note
Two-Stage Breast Cancer Induction Method:
1. At 7 weeks of age, each rat is administered a single dose of 20 mg of DMBA (9,10-dimethyl-1,2-benzanthracene) orally. DMBA is dissolved in sesame oil at a concentration of 2% before use.
2. From 8 to 27 weeks of age, each rat is given a diet containing 1000 ppm of Nitrofurazone daily (ppm: parts per million, indicating the amount of Nitrofurazone per million units of the diet; for example, a concentration of 1000 ppm means 1 g of Nitrofurazone in 1 kg of feed).
Modeling Indicators
Hormonal Changes: Significant increases in serum prolactin and progesterone levels in rats.
Histological Changes: Development of mammary tumors, with the vast majority being adenocarcinomas, and a very small number potentially being fibrosarcomas.
Correlated Product(s): DMBA (HY-W011845)

Your information is safe with us.