Cyclizine (lactate)
CAS No. : 5897-19-8
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| Cat. No. : | HY-B1397B |
| M.Wt: | 356.46 |
| Formula: | C21H28N2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Cyclizine lactate, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine lactate can be used for the research of nausea, vomiting, and dizziness[1][2][3].
In Vitro: Cyclizine (100 μM) lactate significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants[1].
Cyclizine lactate inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 µM[2].
In Vivo: Cyclizine (1-10 mg/kg) lactate enhances locomotor activity of mice in a dose-dependent manner[3].
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