Cyclizine (dihydrochloride)
CAS No. : 5897-18-7
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| Cat. No. : | HY-B1397A |
| M.Wt: | 339.30 |
| Formula: | C18H24Cl2N2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Cyclizine dihydrochloride, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine dihydrochloride can be used for the research of nausea, vomiting, and dizziness[1][2][3].
IC50 & Target: H1 Receptor[1]
In Vitro: Cyclizine (100 μM) dihydrochloride significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants[1].
Cyclizine dihydrochloride inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 µM[2].
In Vivo: Cyclizine (1, 10 mg/kg) dihydrochloride enhances locomotor activity of mice in a dose-dependent manner[3].
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