Sinefungin
CAS No. : 58944-73-3
(Synonyms: Adenosyl-Ornithine; A-9145; Antibiotic 32232RP)
| Size | Price | Stock |
|---|---|---|
| 1mg | $270 | In-stock |
| 5mg | $380 | In-stock |
| 10mg | $600 | In-stock |
| 25mg | $1280 | In-stock |
| 50mg | $2250 | In-stock |
| 100mg | $3950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101938 |
| M.Wt: | 381.39 |
| Formula: | C15H23N7O5 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication[1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation[2].
In Vitro: Sinefungin (0.5 or 1.0 μg/mL, 60 minutes) ameliorates the TGF-β1-induced increase of α-SMA and inhibits the upregulation of histone H3K4 monomethylation in renal epithelial cells and renal fibroblast cells[2].
In Vivo: Sinefungin (10 mg/kg, per day immediately after UUO) ameliorates renal fibrosis in obstructive nephropathy[2].
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