Ambruticin

Ambruticin (W7783) is an orally active and potent antifungal antibiotic. Ambruticin represents a class of antibiotics, that can be isolated from a strain of Polyangium cellulosum var. fulvum, a bacterium belonging to the class Myxobacteriales. Ambruticin is a cyclopropyl-polyene-pyran acid and is active against fungi^[1]. In Vitro:Ambruticin is highly active against the yeast and filamentous phases of H. capsulatum and B. dermatitidis; the MIC range was 0.049 to 0.39 μg/mL, and the order of activity appeared similar to amphotericin B (HY-B0221)^[2].
Ambruticin MIC is 1.56 μg/mL and the Griseofulvin (HY-17583) MIC was 3.12 μg/mL against M.fulvum^[2].
In Vivo:The acute LD₅₀ values for the sodium salt of Ambruticin in mice were: intravenous 315 mg/kg, oral > 1000 mg/kg^[1].
Ambruticin is rapidly absorbed by the oral route in mice. Ambruticin (75 mg/kg, gavage) produces a peak serum level of 46 μg/mL with a serum half-life of 3.1 h^[2].
Ambruticin (40 mg/kg, oral, twice daily for a total of 10 days) shows protective activity in Guinea pigs infected with a severe T. mentagrophytes challenge^[2].
Ambruticin shows protective activity in mice acutely infected with a severe C. albicans challenge^[2].