m-Coumaric acid

m-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant. m-Coumaric acid is a BBB-penetrant metabolite of chlorogenic acid. m-Coumaric acid stimulates the cerebral nerves in vitro. m-Coumaric acid can evoke neurite outgrowth in hippocampal neuronal cells. m-Coumaric acid can promote neuronal differentiation. m-Coumaric acid increases spontaneous locomotor activity in mice by acting on the central nervous system. m-Coumaric acid inhibits the oxidation of L-dopa by epidermis tyrosinase. m-Coumaric acid attenuates non-catalytic protein glycosylation in retinas of diabetic rats^[1][2][3]. In Vitro:m-Coumaric acid (0-0.98 mM) inhibits epidermis tyrosine dose-dependently^[2]. In Vivo:m-Coumaric acid (150-300 mg/kg, i.g., single dose) results in a significant elevation of the GSH level and the activities of catalase and SOD dose-dependently in rat model^[3].