γ-L-Glutamyl-L-alanine
CAS No. : 5875-41-2
(Synonyms: γ-Glu-Ala)
| Size | Price | Stock |
|---|---|---|
| 100mg | $58 | In-stock |
| 250mg | $144 | In-stock |
| 1g | $362 | In-stock |
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| Cat. No. : | HY-112171 |
| M.Wt: | 218.21 |
| Formula: | C8H14N2O5 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 50 mg/mL;DMSO : < 1 mg/mL |
γ-L-Glutamyl-L-alanine (γ-Glu-Ala), composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins. γ-L-Glutamyl-L-alanine is a natural substrate of the γ-Glutamylcyclotransferase. γ-L-Glutamyl-L-alanine is a positive modulator of calcium-sensing receptor (CaR) function[1][2][3][4].
In Vitro: γ-L-Glutamyl-L-alanine (γ-Glu-Ala) shows the potency for Ca2+i mobilization in CaR (calcium-sensing receptor)-expressing HEK-293 cells, with an EC50 of 4.8 μM[3].
γ-L-Glutamyl-L-alanine shows the potency for Ca2+i mobilization in human parathyroid cells with an EC50 of 13.9 μM[3].
γ-L-Glutamyl-L-alanine (20 μM) suppress PTH secretion from normal human parathyroid cells[3].
γ-L-Glutamyl-L-alanine is a substrate for glutaminase B[4].
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