Metaproterenol (hemisulfate)


CAS No. : 5874-97-5

(Synonyms: Metaproterenol sulfate)

5874-97-5
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Cat. No. : HY-B1276
M.Wt: 309.34
Formula: C11H17NO3.1/2H2O4S
Purity: >98 %
Solubility: DMSO : 62.5 mg/mL (ultrasonic)
Introduction of 5874-97-5 :

Metaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity[1][2]. IC50 & Target: IC50: 68 nM (β2-adrenergic receptor)[1] In Vitro: Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages[1].
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages[1]. In Vivo: Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications[1].

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