Dihydrokavain
CAS No. : 587-63-3
(Synonyms: 7,8-Dihydrokawain; 7,8-Dihydrokavain; Marindinin)
| Size | Price | Stock |
|---|---|---|
| 1mg | $85 | In-stock |
| 5mg | $250 | In-stock |
| 10mg | $400 | In-stock |
| 25mg | $720 | In-stock |
| 50mg | $1080 | In-stock |
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| Cat. No. : | HY-N0920 |
| M.Wt: | 232.28 |
| Formula: | C14H16O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Dihydrokavain (7,8-Dihydrokawain) is a natural kavalactone compound. Dihydrokavain inhibits COX-1, COX-2, CYP2C9 (IC50 = 130.95 μM), CYP2C19 (IC50 = 10.05 μM) and CYP3A4 (IC50 = 78.59 μM). Dihydrokavain reduces TNFα secretion. Dihydrokavain shows analgesic and anxiolytic effects[1][2][3][4][5].
In Vitro:Dihydrokavain inhibits COX-1 and COX-2 by approximately 58% and 28%, respectively[1].
Dihydrokavain (50 μg/mL) reduces TNFα secretion in a lipopolysaccharide-stimulated human acute monocytic leukaemia derived cell line (THP-1)[3].
Dihydrokavain inhibits CYP2C9 (IC50 = 130.95 μM), CYP2C19 (IC50 = 10.05 μM) and CYP3A4 (IC50 = 78.59 μM)[4].
In Vivo:Dihydrokavain (150 mg/kg; i.p.) produces an obvious analgesic effect in mice[6].
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