Anagrelide (hydrochloride)
CAS No. : 58579-51-4
(Synonyms: BL4162A)
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $58 | In-stock |
| 25mg | $116 | In-stock |
| 50mg | $187 | In-stock |
| 100mg | $300 | In-stock |
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| Cat. No. : | HY-B0523A |
| M.Wt: | 292.55 |
| Formula: | C10H8Cl3N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 6.36 mg/mL (ultrasonic;warming;heat to 60°C);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36 nM). Anagrelide hydrochloride, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride is a platelet-lowering agent and plays in the antithrombopoietic action[1][2][3].
In Vitro:Anagrelide hydrochloride (BL4162A) potently inhibits the development of marrow megakaryocytes (IC50=26 nM)[1].
Anagrelide (0.05, 0.3, 1 µM; 12-day) hydrochloride inhibits only megakaryocytic cell growth not non-megakaryocytic cells[2].
Anagrelide (0.1-10000 nM) hydrochloride induces a cytotoxic effect in the GIST882 cell line[3].
In Vivo:Anagrelide hydrochloride (BL4162A; 5 mg/kg/bid; for 10 days) hydrochloride inhibits or reduces tumor growth in GIST2B, GIST9, GIST882 model models[3].
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