Losmapimod (Standard)
CAS No. : 585543-15-3
(Synonyms: GSK-AHAB (Standard); GW856553X (Standard); SB856553 (Standard))
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| Cat. No. : | HY-10402R |
| M.Wt: | 383.46 |
| Formula: | C22H26FN3O2 |
| Purity: | >98 % |
| Solubility: |
Losmapimod (GSK-AHAB; GW856553X) (Standard) is the analytical standard of Losmapimod (HY-10402). This product is intended for research and analytical applications. Losmapimod (GSK-AHAB; GW856553X) is an orally active p38α/β MAPK inhibitor, with pKi values of 8.1 and 7.6 for p38α and p38β, respectively. Losmapimod reduces DUX4 expression, thus exerting efficacy in facioscapulohumeral muscular dystrophy. By inhibiting MAPK/NF-κB, Losmapimod reduces apoptosis of epileptiform hippocampal neurons, and exhibits anti-allodynia and anti-hyperalgesic activities. Losmapimod blocks the entry and fusion of Lassa fever virus (LASV). Losmapimod overcomes tyrosine kinase inhibitor resistance in non-small cell lung cancer (NSCLC). Losmapimod inhibits myocardial senescence and inflammation, and possesses cardioprotective activity against cardiotoxicity[1][2][3][4][5][6].
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- Losmapimod (Standard)
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