MK-447
CAS No. : 58456-91-0
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| Cat. No. : | HY-100297 |
| M.Wt: | 305.16 |
| Formula: | C11H16INO |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
MK-447 is a free radical scavenger, also a nonsteroidal antiinflammatory agent, and enhances the formation of the endoperoxide, PGH2, and other prostaglandins. IC50 & Target: Prostaglandin Receptor[1][2] In Vitro: MK-447 is a free radical scavenger, reduces the accumulation of the endoperoxide, PGG2 and also enhances the formation of the endoperoxide, PGH2, and other prostaglandins[1]. MK-447 (100 μM) increases the amounts of prostaglandin I2 (PGI2). MK-447 also accelerates endogenous PGI2 generation in the isolated rat aorta[2]. In Vivo: MK-447 (20 and 50 mg/kg, p.o.) blocks gastric acid secretion in the 4 hour pylorus ligated rats, but shows no effect on gastric secretion of pepsin. MK-447 (5, 10, 20 and 40 mg/kg, p.o.) dose-dependently decreases acid output in dogs[1].
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