Thiazesim
CAS No. : 5845-26-1
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| Cat. No. : | HY-105857 |
| M.Wt: | 326.46 |
| Formula: | C19H22N2OS |
| Purity: | >98 % |
| Solubility: |
Thiazesim is a CNS-penetrant GABAA receptor inhibitor, exerting anticonvulsant and antidepressant effects. Thiazesim depresses amygdala output, disrupts conditioned avoidance response in rats. Thiazesim can be used for the research of depression and epilepsy[1][2][3][4][5].
In Vivo:Thiazesim (1.0-10.0 mg/kg; i.p.) produces no significant reduction in shock-induced defensive fighting, locomotor activity, or shock reactivity in rats[2].
Thiazesim (20 mg/kg; i.p.; daily prior to each acquisition or retention training session) significantly depresses conditioned avoidance response performance in rats during both acquisition and retention phases, without impairing motor escape responses or inducing state-dependent learning[4].
Thiazesim (5-40 mg/kg; i.p.; single dose) blocks all tested unlearned behaviors at nondebilitating doses in rats[5].
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