Aspidin BB
CAS No. : 584-28-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | In-stock |
| 10mg | $395 | In-stock |
| 25mg | $785 | In-stock |
| 50mg | $1250 | In-stock |
| 100mg | $2000 | In-stock |
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| Cat. No. : | HY-108164 |
| M.Wt: | 460.52 |
| Formula: | C25H32O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic) |
Aspidin BB is a phloroglucinol derivative, which can be isolated from the aerial part of Dryopteris championii. Aspidin BB has anticancer activity. Aspidin BB induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells[1][2].
In Vitro:Aspidin BB (0-100 μM, 24-72 h) significantly inhibits HO-8910 cell proliferation in a dose- and time-dependent manner. The IC50 values are 15.02, 25.79 and 68.81 μM after 72, 48 and 24 h treatment, respectively[1].
Aspidin BB suppresses Bcl-2 expression and enhances Bax expression to desintegrate the outer mitochondrial membrane, then causes cytochrome c release which leads to the activation of effector caspase-3, and further cleaves the poly ADP-ribose polymerase (PARP) in the nucleus, finally induces cell apoptosis[1].
Aspidin BB provokes S phase arrest in HO-8910 cells with up-regulation of pRb, E2F1, CDK2, cyclin E and cyclin A proteins[1].
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