EHNA (hydrochloride)
CAS No. : 58337-38-5
| Size | Price | Stock |
|---|---|---|
| 2mg | $50 | In-stock |
| 5mg | $110 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $310 | In-stock |
| 50mg | $580 | In-stock |
| 100mg | $1050 | In-stock |
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| Cat. No. : | HY-103160A |
| M.Wt: | 313.83 |
| Formula: | C14H24ClN5O |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic);DMSO : 83.33 mg/mL (ultrasonic;warming;heat to 60°C) |
EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects[1][2]. In Vitro: EHNA completely ablates the ability of cyclic GMP to activate PDE2 activity, whilst having a much smaller inhibitory effect on the unstimulated PDE2 activity[2].EHNA exhibits normal Michaelian kinetics of inhibition for the cyclic GMP-stimulated PDE2 activity with Hill plots near unity[2].EHNA prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts[3].
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