BMS-265246
CAS No. : 582315-72-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $210 | In-stock |
| 25mg | $386 | In-stock |
| 50mg | $560 | In-stock |
| 100mg | $820 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15275 |
| M.Wt: | 345.34 |
| Formula: | C18H17F2N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic) |
BMS-265246 is a potent and selective cyclin-dependent kinase CDK1 and CDK2 inhibitor, with IC50 values of 6 and 9 nM, respectively. BMS-265246 inhibits CHI3L1 (chitinase 3-like-1) stimulation of ACE2 (angiotensin converting enzyme 2) and SPP (viral spike protein priming proteases). BMS-265246 can be used for ovarian cancer and COVID-19 research[1][2][3].
IC50 & Target: IC50: 6 nM (CDK1/cycB), 9 nM (CDK2/cycE), 230 nM (CDK4/cycD)[1]
In Vitro: BMS-265246 binds at the ATP site and shows cytotoxic activity in ovarian cancer cell (A2780), with an IC50 of 0.76 μM[1].
BMS-265246 (0-10 μM) can dose dependently increase iTreg cell differentiation[2].
BMS-265246 (9 nM, 24 h) inhibits the ability of CHI3L1 to stimulate epithelial cells ACE2 and SPP[3].
BMS-265246 (1 μM, 1 h) prevents E2 induction of EGF3, AREG and CXCL12 in MCF7 cells[4].
BMS-265246 is able to cooperate with Tamoxifen to induce apoptosis in MCF7 cells[4].
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