Terrein

Terrein is a melanogenesis inhibitor^[1]. Terrein induces apoptosis in breast cancer cell lines ^[2]. Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa^[3]. In Vitro: Treatment of Mel-Ab cells with Terrein (10-100 μM) for 4 days significantly reduces melanin levels in a dose-dependent manner. Terrein reduces melanin synthesis by reducing tyrosinase production via ERK activation^[1].
Terrein (5-500 μM; 24 and 48 hours) reduces the viability of these cells in concentration- and time-dependent manners^[2].
Terrein (150, 250, 500μM; 24 hours) induces programmed cell death in both invasive and non-invasive breast cancer cell lines. Thus, the optimal non-toxic concentrations of Terrein (25 and 75 μM) were used for subsequent experiments^[2].
Terrein (25 and 75 μM) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MDA-MB-231 cells. Terrein (75 μM) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MCF-7 cells^[2].
Terrein (75 μM) inhibits the expression of RhoA, RhoB, p-Rac1 in MCF-7 cells. Terrein (75 μM) inhibits the expression of RhoB, p-Rac1 in MDA-MB-231 cells^[2].
Terrein (10, 30, and 100?μM) inhibits the production of virulence factors such as elastase, pyocyanin, and rhamnolipid, as well as biofilm formation in P. aeruginosa PAO1 and PA14 strains^[3].