DSRM-3716
CAS No. : 58142-99-7
(Synonyms: 5-Iodoisoquinoline)
| Size | Price | Stock |
|---|---|---|
| 250mg | $14 | In-stock |
| 1g | $24 | In-stock |
| 5g | $105 | In-stock |
| 10g | $196 | In-stock |
| 25g | $478 | In-stock |
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| Cat. No. : | HY-W021879 |
| M.Wt: | 255.06 |
| Formula: | C9H6IN |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD+-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection[1].
IC50 & Target: IC50: 75 nM (SARM1 NADase)[1]
In Vitro: DSRM-3716 treatment produces dose-dependent inhibition of cADPR increase (IC50 of 2.8 μM) and substantial preservation of NAD+ in these cultures in a manner consistent with engagement and inhibition of SARM1 enzymatic NADase activity inside the cells[1].
DSRM-3716 prevents neurofilament light chain (NfL) release from severed axons in a dose-dependent manner, with an IC50 of ~2 μM[1].
The potency of DSRM-3716 to inhibit cADPR increase caused by axotomy (IC50 of 2.8 μM) is similar to the potency required to prevent axonal degeneration (IC50 of 2.1 μM)[1].
DSRM-3716 inhibits the SARM1-dependent cell destruction pathway triggered by Rotenone in sensory neurons[1].
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