Militarine

Militarine is a plant growth inhibitor and anti-inflammatory agent. Militarine inhibits the elongation of radicles and hypocotyls in seedlings of lettuce, Italian ryegrass and timothy grass. Militarine alleviates PM_2.5-induced inflammatory injury and inhibits cell migration in human alveolar epithelial A549 cells by inhibiting the NF-κB signaling pathway, reducing oxidative stress and the release of inflammatory factors. Militarine can be used in studies related to PM_2.5-induced pulmonary diseases^[1][2]. In Vitro:Militarine (52 h) inhibits the elongation of radicles and hypocotyls in seedlings of lettuce (Lactuca sativa L. cv. Great Lakes 366), with an EC₅₀ value of 0.28 mM for radicles and 1.03 mM for hypocotyls^[1].
Militarine (52 h) inhibits the elongation of radicles and hypocotyls in seedlings of Lolium multiflorum Lam., with an EC₅₀ value of 0.43 mM for radicles and 1.18 mM for hypocotyls^[1].
Militarine (58 h) inhibits the elongation of radicles and hypocotyls in Phleum pratense L. seedlings, with corresponding EC₅₀ values of 0.32 mM and 0.82 mM for radicles and hypocotyls, respectively^[1].
Militarine (1.25-60 μg/mL; 24 h) reduces the viability of A549 cells^[2].
Militarine (1.25-10 μg/mL; 20 h) reduces the secretion levels of IL-6 and TNF-α in A549 cells exposed to PM_2.5^[2].
Militarine (1.25-10 μg/mL; 20 h) inhibits the mRNA expression of IL-6, TNF-α, IL-1β and COX-2, and reduces the accumulation level of ROS in PM_2.5-exposed A549 cells^[2].
Militarine (1.25-10 μg/mL; 20 h) reduces the apoptosis level of A549 cells after PM_2.5 exposure, and inhibits cell migration and invasion^[2].
Militarine (1.25-10 μg/mL; 20 h) inhibits the activation of the NF-κB pathway by reducing the phosphorylation levels of IKKβ, IκBα and NF-κBp65 in A549 cells exposed to PM_2.5; in addition, 5 and 10 μg/mL Militarine reduces the COX-2 protein level in PM_2.5-exposed cells after 18 h of exposure^[2].