SU4312


CAS No. : 5812-07-7

5812-07-7
Price and Availability of CAS No. : 5812-07-7
Size Price Stock
5mg $83 In-stock
10mg $140 In-stock
25mg $280 In-stock
50mg $448 In-stock
100mg $716 In-stock
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Cat. No. : HY-100349
M.Wt: 264.32
Formula: C17H16N2O
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic)
Introduction of 5812-07-7 :

SU4312 is the racemate of (Z)-SU4312 and (E)-SU4312. (Z)-SU4312 inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. (E)-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively[1]. In Vitro: Receptor tyrosine kinases (RTKs) have been shown to be important mediators of cellular signal transduction in cells. Many RTKs have been shown to be oncogene products implicating their role in the transformation process associated with human cancers[1].

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