α-MSH
CAS No. : 581-05-5
(Synonyms: α-Melanocyte-Stimulating Hormone)
| Size | Price | Stock |
|---|---|---|
| 1mg | $66 | In-stock |
| 5mg | $198 | In-stock |
| 10mg | $343 | In-stock |
| 25mg | $739 | In-stock |
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| Cat. No. : | HY-P0252 |
| M.Wt: | 1664.88 |
| Formula: | C77H109N21O19S |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 12.5 mg/mL;DMSO : 100 mg/mL (ultrasonic) |
α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC)[1][2]. IC50 & Target:MC4R[2] In Vitro: α-MSH modulates CNS inflammation by acting directly on melanocortin receptors in glial cells. α-MSH modulates NFκB activation. α-MSH inhibits translocation of transcription factor κB to the nucleus[3]. In Vivo: α-MSH (50 μg/0.2 ml saline; i.p.) given systemically effectively modulates inflammatory reactions[3].
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