Diphenhydramine
CAS No. : 58-73-1
| Size | Price | Stock |
|---|---|---|
| 5g | $30 | In-stock |
| 25g | $83 | In-stock |
| 100g | $211 | In-stock |
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| Cat. No. : | HY-B0303 |
| M.Wt: | 255.36 |
| Formula: | C17H21NO |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) [1][2][3].
In Vitro:Diphenhydramine (1-300 μM, 30 s) can block NMDA-activated membrane currents. This property can be responsible for or add to its sedative, analgesic and memory related effects[2].
In Vivo:Diphenhydramine (0-10 mg/kg, i.v. and p.o.) has better oral bioavailability when used in combination with Dimenhydrinate (HY-B1215)sup>[3].
Diphenhydramine (20 mg/kg, i.p.) can improve the kidney injury induced by Cisplatin (CDDP) (HY-17394) in mice, and does not affect the anti-tumor efficacy of Cisplatin[4].
Pharmacokinetic parameters for diphenhydramine after single oral or intravenous administration of diphenhydramine HCl (5 mg/kg) to six healthy dogs by using a noncompartmental model with first-order elimination[3]
| Route | Dose (mg/kg) | AUClast (ng·h/mL) | C0 (ng/Ml) | CL (Ml/h/kg) | T1/2 (h) | Kel (1/h) | MRT (h) | Vss_obs (mL/kg) | Cmax (ng/mL) | Tmax (h) | Vz (mL/kg) | F (%) |
| i.v. | 5 | 391.20 | 266.10 | 2833.04 | 1.89 | 0.45 | 2.47 | 6582.36 | / | / | / | / |
| p.o. | 5 | 153.80 | / | / | 4.98 | 0.59 | 6.97 | / | 35.80 | 1.30 | 180157.36 | 7.75 |