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Inosine


CAS No. : 58-63-9

58-63-9
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Cat. No. : HY-N0092
M.Wt: 268.23
Formula: C10H12N4O5
Purity: >98 %
Solubility: DMSO : 25 mg/mL (ultrasonic);H2O : 10 mg/mL (ultrasonic)
Introduction of 58-63-9 :

Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors[1][2][3]. In Vitro:Inosine dose-dependently stimulates cAMP production mediated through the A2AR[2].
Inosine dose-dependently induces hA2AR-mediated ERK1/2 phosphorylation[2].
Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes[3].
In Vivo:Inosine can induce hyperuricemia[5].

Induction of Hyperuricemia[5]
Background
Hyperuricaemia (HUA) occurs because of purine metabolism aberrations and is typically characterized by increased uric acid formation or reduced uric acid excretion. Inosineis a precursor of purine metabolism. Purine nucleoside phosphorylase (PNP) and xanthine oxidase (XO) catalyse the conversion of inosine [6]. Inosinecan further catalyzed hypoxanthine, xanthine and uric acid (UA)[7].
Specific Mmodeling Methods
Mice: Alb-CreERT2;Glut9lox/lox (LG9KO) &bulll; 6-week-old
Administration: 4 g/kg • ig • one time daily at 9: 00-10: 00 A.M. for 3 days
Note
(1)Mice was gavaged one time daily at 9:00–10:00 A.M. for 3 days (days 0, 1, and 2) with 4 g/kg inosine (500 mg/ml in 0.5% carboxymethylcellulose aqueous suspension) and euthanized 24 h after the last inosine gavage (day 3).
(2)Blood was collected from tail bleeds for plasma urate and creatinine measurements before the inosine treatment and 2 h, 6 h after the first gavage, and 24 h after the last gavage before the animals were euthanized.
(3)Six weeks after inosine gavage, plasma urate and creatinine had normalized.
Inosine gavage combines with HFD to cause acute renal failure in LG9KO mice.
Modeling Indicators
Molecular changes: Inosine elevates plasma urate levels in LG9KO mice. In LG9KO mice fed chow, uricemia transiently rose 2 and 6 h after the first gavage and returned to their basal level 24 h after the last gavage (day 3). In contrast, in HFD-fed LG9KO mice, inosine gavage induced a much higher hyperuricemia at day 3
Tissue changes: leads to tubular urate and uric acid crystal formation.
Correlated Product(s): Potassium oxonate (HY-17511)
Opposite Product(s): /

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