Angiotensin II 5-valine
CAS No. : 58-49-1
(Synonyms: Valine angiotensin II; 5-L-Valine angiotensin II)
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $78 | In-stock |
| 50mg | $90 | In-stock |
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| Cat. No. : | HY-P0108 |
| M.Wt: | 1032.15 |
| Formula: | C49H69N13O12 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
Angiotensin II 5-valine is an agonist of angiotensin receptor. IC50 & Target: Angiotensin receptor[1]. In Vivo: By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone[1].
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