Dipyridamole
CAS No. : 58-32-2
| Size | Price | Stock |
|---|---|---|
| 100mg | $66 | In-stock |
| 500mg | $86 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-B0312 |
| M.Wt: | 504.63 |
| Formula: | C24H40N8O4 |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL;DMSO : ≥ 50 mg/mL |
Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor. Dipyridamole also is an antiplatelet agent used in secondary prophylaxis against stroke. Dipyridamole can induce cancer cell-specific apoptosis[1][2][3]. IC50 & Target:PDE In Vitro:Dipyridamole (5 μM; 15 min) results in a 2.5-fold increase in intracellular cAMP levels in OCI-AML-3 cells[2]. Dipyridamole (5 μM; 48 h) with the statin combination induces apoptosis in primary AML cells[2]. Dipyridamole (5 μM; 48 h) possesse cAMP/PKA-independent activity against statininduced SREBP2 activation[2]. In Vivo:Dipyridamole (10 mg/kg; p.o. once daily for 18 d) mitigates tumor growth, ameliorated concurrent alterations in blood circulation and tumor tissues, and platelet infiltration in tumor tissues[3].
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