GW806742X
CAS No. : 579515-63-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $28 | In-stock |
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $150 | In-stock |
| 50mg | $240 | In-stock |
| 100mg | $375 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-112292 |
| M.Wt: | 573.55 |
| Formula: | C25H22F3N7O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
GW806742X, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X has activity against VEGFR2 (IC50=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis[1][2]. IC50 & Target: Kd: 9.3 μM (MLKL)[1] In Vitro: GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD-OPh) in a dose-dependent manner[1]. GW806742X shows inhibition of VEGF induced proliferation of HUVECs with an IC50 of 5 nM[2].
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- GW806742X
- Cat. No.:
- HY-112292
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