Bax inhibitor peptide V5
CAS No. : 579492-81-2
(Synonyms: BIP-V5; BAX Inhibiting Peptide V5)
| Size | Price | Stock |
|---|---|---|
| 5mg | $119 | In-stock |
| 10mg | $185 | In-stock |
| 25mg | $396 | In-stock |
| 50mg | $660 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-P0081 |
| M.Wt: | 586.79 |
| Formula: | C27H50N6O6S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : 100 mg/mL (ultrasonic) |
Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, used for cancer treatment. In Vitro: Bax inhibitor peptide V5 (BIP-V5; 0-50 μM) reduces cell death in STF-cMyc cells but not in SW620 or NCI-H23 cells. BIPV5 does not result in any significant effect on cell cycle arrest at the G2/M phase[1]. V5 treatment upregulates expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB-p65 by 10, 30, and nearly 50%, respectively[2]. In Vivo: Bax inhibitor peptide V5 (BIP-V5; 100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model[2].
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