Oligomycin A
CAS No. : 579-13-5
(Synonyms: MCH 32)
| Size | Price | Stock |
|---|---|---|
| 1mg | $80 | In-stock |
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $480 | In-stock |
| 50mg | $768 | In-stock |
| 100mg | $1230 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-16589 |
| M.Wt: | 791.06 |
| Formula: | C45H74O11 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);Ethanol : 100 mg/mL (ultrasonic;heat to 60°C) |
Oligomycin A (MCH 32), created by Streptomyces, acts as a mitochondrial F0F1-ATPase inhibitor, with a Ki of 1 μM; Oligomycin A shows anti-fungal activity. IC50 & Target: Ki: 1 μM (F0F1-ATPase)[1] In Vitro: Oligomycin A is a mitochondrial F0F1-ATPase inhibitor with a Ki of 1 μM. Oligomycin A shows cytotoxic to the NCI-60 cell lines, with GI50 of 10 nM. Oligomycin A also inhibits the activity of Triton X-100-solubilized ATPase with a Ki of 0.1 μM. Furthermore, Oligomycin A has anti-fungal activity[1]. Oligomycin A (2.4 µM) inhibits the ability of spermatozoa to achieve feasible in vitro capacitation (IVC), and also suppresses progesterone-induced in vitro acrosome exocytosis (IVAE) as well as the concomitant peaks of O2 consumption and ATP levels[2].
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