ABTL-0812
CAS No. : 57818-44-7
(Synonyms: α-Hydroxylinoleic acid)
| Size | Price | Stock |
|---|---|---|
| 1mg | $150 | In-stock |
| 5mg | $375 | In-stock |
| 10mg | $635 | In-stock |
| 50mg | $1900 | In-stock |
| 100mg | $2950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-U00141 |
| M.Wt: | 296.44 |
| Formula: | C18H32O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
ABTL-0812 (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. ABTL-0812 is a first-in-class small molecule with anti-cancer activity[1].
In Vitro: ABTL-0812 (ABTL0812; 10-100 μM; 48 hours) inhibits cell viability of squamous NSCLC H157 cells[1].
Compared with squamous NSCLC H157 cells, human lung fibroblast cell line MRC-5 are resistant to ABTL0812 treatment[1].
In Vivo: ABTL-0812 (ABTL0812; 120 mg/kg; oral gavage; 5 times per week; for 33 d) induces ER stress in human lung and pancreatic xenografts[1].
ABTL-0812 induces hallmarks of ER stress in vivo. ABTL-0812 increases ATF4 and HSPA5 expression in mice bearing MiaPaca2 and A549 xenograft, respectively[1].
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