Domperidone
CAS No. : 57808-66-9
(Synonyms: R33812)
| Size | Price | Stock |
|---|---|---|
| 100mg | $66 | In-stock |
| 200mg | $119 | In-stock |
| 500mg | $198 | In-stock |
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| 5 g | Get quote | |
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| Cat. No. : | HY-B0411 |
| M.Wt: | 425.91 |
| Formula: | C22H24ClN5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic) |
Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1].
In Vitro: Cardiac Na+ channels are common targets of therapeutics inducing cardiotoxicity[3].
Domperidone (0-1000 μM) displays concentration- and state-dependent inhibitory of Nav1.5 in Human embryonic kidney HEK293 cells[3].
Domperidone (0, 10, 100 μM) displays tonic and use-dependent block to Na currents in rat cardiomyocytes with a IC50 of 312 μM[3].
In Vivo: Unlike Metoclopramide, Domperidone (R33812) does not cause any adverse neurological symptoms as it has minimal penetration through the blood-brain barrier[1].
Domperidone acts as both an antiemetic and an upper gastrointestinal tract prokinetic agent. It is rapidly absorbed after oral administration, and few side effects have been reported[2].
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