Closantel


CAS No. : 57808-65-8

57808-65-8
Price and Availability of CAS No. : 57808-65-8
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Cat. No. : HY-17596
M.Wt: 663.07
Formula: C22H14Cl2I2N2O2
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL
Introduction of 57808-65-8 :

Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing[1][2]. In Vitro:Closantel, a known anthelmintic drug, is highly specific forfilarial family chitinases compared to those fromprotozoans and the human chitinase, human chitotriosidase[1].

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